Wednesday, May 23, 2018

Nipah Virous- viral threat to human health

The Nipah virus has so far claimed 10 lives in Kozhikode and Malappuram districts in north Kerala while the condition of two persons undergoing treatment for the viral disease is said to be critical, according to state Health Minister K K Shylaja.
The World Health Organization (WHO) had been informed about the outbreak of the virus in Kerala, she told reporters on Tuesday.

Two persons -- Rajan and Ashokan, who were undergoing treatment at Kozhikode and died this morning, had been confirmed to have contracted the virus, she said. A nursing assistant, Lini, who died yesterday had also contracted the virus.

Of the 18 samples sent for testing, 12 have tested positive for the virus. Of those who tested positive, 10 have died.

Two deaths reported on May 20 from Malappuram -- Sindhu and Sijitha -- also tested positive for the Nipah virus. The two had come to Kozhikode Medical College Hospital for treatment and had been in touch with one of the infected persons who later died of the virus, the minister said.

No fresh case has been reported so far, she said, adding that Union Health minister J P Nadda, who is in Geneva, had called her and enquired about the situation in the state and has promised all help from the central government.

The Centre on Monday sent a multi-disciplinary National Centre for Disease Control (NCDC) team. A high level team from AIIMS also reached the state.


In a series of tweets on Monday evening, Kerala Chief Minister Pinarayi Vijayan's office said the "government is closely monitoring the spread of the Nipah virus. Health department is doing everything possible to save the lives of the infected & prevent the advance of virus".

CM Vijayan further assured that the state's health minister and labour minister were camped at the affected district of Kozhikode to lead the relief efforts. Private hospitals had also been instructed to not deny treatment to anyone suffering from fever, Vijayan said.


CM Pinarayi Vijayan has informed that Government is closely monitoring the spread of the Nipah virus. Health department is doing everything possible to save the lives of the infected & prevent the advance of virus.

— CMO Kerala (@CMOKerala) May 21, 2018
National Institute of Virology has confirmed from the studies on blood samples that 3 out of the 4 deaths attributed to fever was caused by the virus. The first death was reported on 19th ; the Union Health Ministry & World Health organization were contacted on the day itself.

— CMO Kerala (@CMOKerala) May 21, 2018
Health minister & Labour minister have camped at the district to lead the efforts. Private hospitals have been instructed to not deny treatment for anyone suffering from fever. An expert medical team of the Union government has arrived on the request of the State Government.

— CMO Kerala (@CMOKerala) May 21, 2018

Vijayan also informed of a state-wise alert to remain vigilant in order to check the spread of the virus-borne disease. "Though the virus has been reported only in Kozhikode, a statewide alert has been given to remain vigilant. A 24-hour control room has been opened to monitor the situation. CM has also requested all to follow the instructions of the health department to tackle this crisis," Vijayan's office said in a tweet.


Though the virus has been reported only in Kozhikode, a statewide alert has been given to remain vigilant. A 24-hour control room has been opened to monitor the situation. CM has also requested all to follow the instructions of the health department to tackle this crisis.      इस बीमारी से बचने के लिए फलों में खासकर खजूर खाने से बचना चाहिए. इसके साथ अगर रात में कोई फल पेड़ से गिर गया तो उसे नहीं खाना चाहिए. साथ ही बीमार सुअर और दूसरे जानवरों से दूरी बनाए रखे.

Symptoms to precaution, all you must know

Named after an area in Malaysia where the first outbreak of the viral fever was reported, Nipah is understood to have a mortality rate of 70 per cent. Here are a few important things to know about the virus, nipah virus symptoms in humans, its immediate outbreak in Kerala, and precautions:

The Nipah virus infection:

The WorlThe World Health Organization (WHO) describes Nipah virus (NiV) infection as a "newly emerging zoonosis that causes severe disease in both animals and humans". The natural host of the virus, according to WHO, are fruit bats of the Pteropodidae family, Pteropus genus (fruit-eating species).

How does Nipah virus infection spread and what are the symptoms?

The transmission of the Nipah virus takes place through the following means:
Direct contact with infected bats
Direct contact with infected pigs
Direct contact with other NiV-infected people
The infection with Nipah virus is associated with encephalitis (inflammation of the brain), says the Center for Disease Control and Prevention. The tell-tale signs of somebody having been infected by the Nipah virus are the following:
An infected person shows symptoms of fever and headache in 3-14 days of exposure and an incubation period of five to 14 days
Clinical signs are fever, headache, dizziness and vomiting, followed by drowsiness, disorientation and mental confusion
More than 50 per cent of the patients face a reduced level of consciousness and prominent brain-stem dysfunction
Some patients have a respiratory illness during the early part of their infections, and half of the patients with severe neurological signs also show pulmonary signs
 State govt. closely monitoring outbreak of Nipah Virus: Kerala CM

The origin of the Nipah virus
The Nipah virus was first identified in Malaysia's Kampung Sungai Nipah in 1998
Pigs were understood to be the intermediate hosts during that outbreak
Around 1.1 million pigs had to be culled to control the outbreak
But a Nipah outbreak need not necessarily have an intermediate host


The earlier instances of Nipah outbreak in India
In India, Nipah Virus affected the humans without any involvement of pigs
The first outbreak was observed in Siliguri, West Bengal in 2001
The second incident also emerged in West Bengal, in Nadia district in 2007
Scientists found humans contracted the disease by drinking raw date palm sap tapped directly from trees

Nipah virus toll: The Nipah virus claimed over 300 lives across Malaysia, Singapore, Bangladesh and India between 1998 and 2008, according to WHO.

Global instances of Nipah outbreak
Bangladesh recorded several Nipah outbreaks in humans almost every year from 2001 to 2013
The virus has also been detected in Cambodia, Thailand, Indonesia, Madagascar in Southern Africa and Ghana in West Africa on fruit bats or bats seropositive to NiV antibodies, according to a 2013 ICMR-sponsored research paper.
Nipah Virus spreading through direct contact

The treatments of the Nipah virus
According to WHO, there is no vaccine currently available for either humans or animals
NiV-infected patients are currently limited to supportive care
People have also been cautioned that they should not consume fruits that have fallen on to the ground

What doctors' say about the Nipah virus diagnosis

According to Dr Atul Gogia, senior consultant, Department of Medicine, Sir Ganga Ram Hospital Nipah is just another viral infection that affects the respiratory and central nervous systems with symptoms like drowsiness. "Like most other viral infections, Nipah also has no treatment and can only be managed through intensive supportive care," he says. The senior doctor does not rule out the possibility of an infected person travelling to other parts of the country and spreading the disease, but he affirms that at present there is no threat in other parts of the country.

one injection could prevent the paralysis caused by the poliovirus

A group of scientists from Massachusetts Institute of Technology (MIT) has developed a new nanoparticle vaccine that could assist efforts to eradicate polio worldwide.

The novel vaccine which delivers multiple doses in just one injection could prevent the paralysis caused by the poliovirus. The vaccine could make it easier to immunise children in remote regions of Pakistan and other countries where the disease is still found.

According to the US Centers for Disease Control, although the number of reported cases of polio dropped by 99 per cent worldwide between 1988 and 2013, the disease has not been completely eradicated because of the difficulty in reaching out to children in remote areas.

“When a one-shot vaccine can elicit full protection, it could be very valuable in being able to achieve eradication,” said Ana Jaklenec, a research scientist at MIT’s Koch Institute for Integrative Cancer Research in Cambridge, US.

In the study, the investigators developed nanoparticles that would deliver an initial burst of the vaccine at the time of injection, followed by a second release after approximately 25 days.

The researchers injected the developed nanoparticles into rats and later obtained blood samples, finding that the samples had a similar or superior antibody response to the poliovirus as samples obtained from mice given two doses of the Salk vaccine.

“The goal is to ensure that everyone globally is immunised,” said Jaklenec, adding “child
ren in some of these hard-to-reach developing world locations tend to not get the full series of shots necessary for protection.”MIT scientists have developed a new nanoparticle vaccine that could assist efforts to eradicate polio worldwide.

The vaccine, which delivers multiple doses in just one injection, could make it easier to immunise children in remote regions of Pakistan and other countries where the disease is still found.

While the number of reported cases of polio dropped by 99 per cent worldwide between 1988 and 2013, according to the US Centers for Disease Control, the disease has not been completely eradicated, in part because of the difficulty in reaching children in remote areas to give them the two to four polio vaccine injections required to build up immunity.

"Having a one-shot vaccine that can elicit full protection could be very valuable in being able to achieve eradication," said Ana Jaklenec, a research scientist at Massachusetts Institute of Technology (MIT) in the US.

"We are very excited about the approaches and results in this paper, which I hope will someday lead to better vaccines for patients around the world," Langer said.

There are no drugs against poliovirus, and in about one per cent of cases, it enters the nervous system, where it can cause paralysis.

The first polio vaccine, also called the Salk vaccine, was developed in the 1950s.

This vaccine consists of an inactivated version of the virus, which is usually given as a series of two to four injections, beginning at 2 months of age.

In 1961, an oral vaccine was developed, which offers some protection with only one dose but is more effective with two to three doses.

The oral vaccine, which consists of a virus that has reduced virulence but is still viable, has been phased out in most countries because in very rare cases, it can mutate to a virulent form and cause infection.

It is still used in some developing countries, however, because it is easier to administer the drops than to reach children for multiple injections of the Salk vaccine.

For polio eradication efforts to succeed, the oral vaccine must be completely phased out, to eliminate the chance of the virus reactivating in an immunised person.

"The goal is to ensure that everyone globally is immunized.

Children in some of these hard-to-reach developing world locations tend to not get the full series of shots necessary for protection," Ana Jaklenec, a research scientist at MIT.

To create a single-injection vaccine, researchers encapsulated the inactivated polio vaccine in a biodegradable polymer known as PLGA.


This polymer can be designed to degrade after a certain period of time, allowing the researchers to control when the vaccine is released.

The researchers designed particles that would deliver an initial burst at the time of injection, followed by a second release about 25 days later.

They injected the particles into rats, and found that the blood samples had an antibody response against poliovirus just as strong as, or stronger than, antibodies from rats that received two injections of Salk polio vaccine.

Researchers said that they could design vaccines that deliver more than two doses - each a month apart.

The researchers are also working on applying this approach to create stable, single-injection vaccines for other viruses such as Ebola and HIV.

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Tuesday, May 22, 2018

STUDY


Important for Upcoming exams....SSC,RAILWAY,BANK..

Number Series

Find Wrong Number and Give your answer in the comment section....

1.      7, 4, 5, 9, 18, 52.5, 160.5


2.      5, 6, 33, 158, 374, 1230, 2561


3.      828, 424, 220, 116, 64, 33


Monday, May 21, 2018

Nokia X6 launched in China

HMD global has launched a new smartphone under its Nokia X series in China called Nokia X6. It will go on sell in China from 21st May.
There is no word about Global availability of Nokia X6 yet.
Key Specifications-
GENERAL
Release date
May 2018
Form factor
Touchscreen
Dimensions (mm)
147.20 x 70.98 x 8.59
Weight (g)
151.00
Battery capacity (mAh)
3060
Colours
Black, Blue, White

DISPLAY
Type     -  IPS LCD capacitive touchscreen, 16M        colors
Size              - 5.8 inches, 84.0 cm2 (~80.3% screen-to-body ratio)
Resolution   -1080 x 2280 pixels, 19:9 ratio (~435 ppi density)
Multitouch -Yes
Protection -Corning Gorilla Glass 3
HARDWARE
Processor
octa-core
Processor make
Qualcomm Snapdragon 636
RAM
4GB/6GB
Internal storage
32GB/64GB
Expandable storage
Yes
Expandable storage type
microSD up to 256 GB

CPU                Octa-core 1.8 GHz Kryo 260

GPU        Adreno 509

CAMERA
Primary Dual:    16 MP (f/2.0, 1.0µm, giro-EIS) + 5 MP (f/2.2, 1.2µm), phase detection autofocus, dual-LED dual-tone flash
Features      -Geo-tagging, touch focus, face detection, panorama, HDR
Video             -1080p@30fps
Secondary    - 16 MP (f/2.0, 1.0µm)
SOFTWARE
Operating System
Android 8.1 (Oreo)
CONNECTIVITY
Wi-Fi
Yes
Wi-Fi standards supported
802.11 a/b/g/n/ac
GPS
Yes
Bluetooth
Yes, v 5.00
USB OTG
Yes
Headphones
3.5mm
Number of SIMs
2
SIM 1
SIM Type
Nano-SIM Hybrid
GSM/CDMA
GSM
3G
Yes
4G/ LTE
Yes
Supports 4G in India (Band 40)
Yes
SIM 2
SIM Type
Nano-SIM Hybrid
GSM/CDMA
GSM
4G/ LTE
Yes
Supports 4G in India (Band 40)
Yes
SENSORS
Compass/ Magnetometer
Yes
Proximity sensor
Yes
Accelerometer
Yes
Ambient light sensor
Yes
Gyroscope
Fingerprint sensor
Yes
 Quick Charge 3.0. Connectivity features include

The Nokia X6 price is 1299 Yuan or about 250 EUR. It comes in Blue, Black and Silver colour.